GAMUT D-81-S6
PRECURSORS OF MALIGNANCY IN BONE


Precursor Condition Comment
Enchondroma very low risk with solitary lesion, higher risk with multiple lesions
Osteochondroma very low risk with solitary lesion, higher risk with multiple lesions
Paget's disease  higher risk with more extensive, polyostotic disease
Radiation injury low risk with 7000 rads or less
Osteomyelitis with chronic        
   sinus tract
long latency period (20+ years)
Bone infarct rare, 90% or more have multiple infarcts
Fibrous dysplasia case reports
Metallic implants case reports
Bone cysts case reports
Osteogenesis imperfecta case reports
Genetic predisposition association with mutant Rb gene and retinoblastoma
Synovial chondromatosis case reports
Giant cell tumor rare malignant recurrence after treatment
Osteoblastoma rare locally aggressive form that does not metastasize
Osteofibrous dysplasia coexistent with adamantinoma, possibly subsets of the same disease